Each variant changes the pay table and the strategy. Jokers wild adds a joker that counts as any card, and deuces games make every two wild, with loose deuces paying extra for four of them. Bonus poker pays more for certain four of a kind hands, and quick quads adds a side wager on them. Multi hand video poker, common online, plays one hold across several hands at once, raising the stake per deal. Plain jacks or better has the lowest variance of the common games.
Video poker can be beaten only in narrow cases. On a few full pay machines, perfect strategy combined with cash back or comps can push the return above one hundred percent, which is what advantage play means here. Almost everywhere else the game is not profitable over time. Casinos control which pay table a machine carries, not which cards it deals: regulated machines draw from a random shuffle, so they are not rigged, but a weaker pay table costs more without saying so.